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About

SetPoint Medical is a commercial-stage medical technology company founded in 2007. The company focuses on developing innovative therapies for chronic autoimmune diseases by integrating scientific discovery, precision engineering, and business expertise. Its flagship product, the FDA-approved SetPoint System, is a neuroimmune modulation device designed for adults with moderate-to-severe rheumatoid arthritis who do not respond adequately to or cannot tolerate existing advanced therapies. The SetPoint System delivers targeted electrical stimulation to the vagus nerve, activating the body’s anti-inflammatory pathways. This approach reduces systemic inflammation and restores immunologic balance without broadly suppressing the immune system. Clinical evidence indicates that a single one-minute stimulation can significantly suppress inflammatory cytokines for over 24 hours. SetPoint Medical plans to expand the availability of the SetPoint System across the U.S. following its initial launch in targeted cities in 2025, with ongoing studies for other chronic autoimmune conditions. Led by CEO Murthy V. Simhambhatla, Ph.D., SetPoint Medical collaborates with healthcare providers and payers to enhance access to its therapy, aiming to improve patient outcomes and quality of life.

Technologies
Route 53 Outlook Render Remote
Keywords
inflammatory diseases neuromodulation autoimmune disease rheumatoid arthritis vagus nerve stimulation biotechnology life sciences medical equipment manufacturing clinical research implantable device systemic anti-inflammatory inflammatory reflex neuroimmune modulation investigational device systemic immune response ra treatment medical equipment and supplies manufacturing autoimmune conditions medical device b2b pioneering bioelectronic therapy chronic inflammation immune-restorative effect fda breakthrough device autoimmune diseases treatment autoimmune therapy autoimmune disease innovation neurostimulation therapy targeted electrical stimulation autoimmune diseases
Company Information
  • Employees 87
  • Founded 2007
  • Annual Revenue $22600000
  • Total Funding $444699986
Location

25101 Rye Canyon Loop, Santa Clarita, California, United States, 91355

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